The Ultimate Cause of Rheumatoid Arthritis
By Karen Reed
Do you suffer from rheumatoid arthritis or know someone who does? If you answered, “yes” to one of these questions, you might be curious about the ultimate cause of rheumatoid arthritis. Today, we’re going to discuss this cause. Our facts come from authority resources, so they are very trustworthy. We want to provide you with current and accurate information which helps you to understand this common health problem in more depth.
Hard Facts About Arthritis Causes
The root cause of rheumatoid arthritis is, sadly, still a bit of a mystery. That’s the truth. However, physicians understand that immune system malfunction plays a key role in the symptoms of rheumatoid arthritis, which include joint inflammation and damage to joints.
What isn’t fully understood is why the immune systems of some people malfunction and trigger the disorder. There is some evidence, which is backed up by clinical studies, which indicates that immune system malfunctioning may be linked with genetics, hormone levels, and environmental elements.
For example, studies have demonstrated the people who have genetic markers (HLA epitope markers) have five times the chance of suffering from rheumatoid arthritis, versus those who don’t have the HLA shared epitope marker. This marker is responsible for immune system responsiveness.
HLA epitope isn’t the only gene which is involved in the development of this form of arthritis. Other genes which play a role include STAT4, which regulates and activates the immune system, as well as C5 and TRAF1. These last two genes are linked with inflammation which is chronic.
Also, the PTPN22 gene is linked with getting the condition and with its progression. However, some people have these genetic markers and don’t get the condition.
At present, scientists and medical experts are delving deeper into the possible causes of rheumatoid arthritis. Some other possible causes which are being studied include viruses and germs. Both may spark the development of the disorder in people who have genes which put them at higher risk.
As well, the role that female hormone play in the development of rheumatoid arthritis is being researched. Currently, seventy percent of rheumatoid arthritis sufferers are women. Also, research is exposing the role of environmental agents which may raise the risk, and these include tobacco smoke exposure, pollution in the air, as well as exposure to insect-killing chemicals (pesticides) and on-the-job exposure to silica and mineral oils.
The Centers for Disease Control estimate that one and a half million USA citizens suffer from rheumatoid arthritis. It’s much more common in females, as we already mentioned, and a total of four percent of USA females will get a diagnosis of rheumatoid arthritis during their lifetimes.
In general, it’s diagnosed more often when people are forty years of age or older. However, younger people and kids get it, too. Overall, most sufferers are over the age of fifty-five, and they are female.
This condition is a …read more
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